J Obstet Gynaecol Res. 2013 May;39(5):1070-2. doi: 10.1111/j.1447-0756.2012.02068.x. Epub 2013 Feb 4.

Pregnancy following ovarian induction in a patient with premature ovarian failure and undetectable serum anti-Müllerian hormone.

Tsuji I1, Ami K, Fujinami N.

Author information復旦大學附屬婦產(chǎn)科醫(yī)院婦科史穎莉

1Department of Obstetrics and Gynecology, Kinki University Faculty of Medicine, Osaka, Japan. [email protected]

Abstract

We report the first case, to the best of our knowledge, of successful conception following ovarian induction in a patient with premature ovarian failure and undetectable serum anti-Müllerian hormone. A 34-year-old woman was referred because of ovarian amenorrhea. After endogenous gonadotrophins were normalized by hormone-replacement therapy and gonadotrophin-releasing hormone agonist, ovarian induction was performed using exogenous gonadotrophins. On ovarian induction day 8, one follicle had reached a mean diameter of 19.6 mm, the serum estradiol level had increased to 516 pg/mL, and human chorionic gonadotrophin (HCG) was injected. On HCG injection day 7, ultrasonography was unable to detect the follicle, and serum progesterone levels had increased to 6.1 ng/mL. One month after HCG injection, ultrasonography detected an intrauterine fetus with beating heart. Even with serum anti-Müllerian hormone levels below the threshold of detection, there is a chance for patients with premature ovarian failure.